immunogenicity of amino acid region 7601-8140 in biofilm associated protein of acinetobacter baumannii

Biofilm formation in Acinetobacter baumannii.

Acinetobacter baumannii has received much attention in recent years because of its increasing involvement in a number of severe infections and outbreaks occurring in clinical settings, and presumably related to its ability to survive and persist in hospital environments. The treatment of infections caused by A. baumannii nosocomial strains has become increasingly problematic, due to their intri...

Study of the immunogenicity of outer membrane protein A (ompA) gene from Acinetobacter baumannii as DNA vaccine candidate in vivo

Objective(s): Acinetobacter baumannii is one the most dangerous opportunistic pathogens in hospitalized infections. This bacterium is resistant to 90% of commercial antibiotics. Therefore, developing new strategies to cure A. baumannii-infections is urgent. The DNA vaccines new approach in which the immunogen can be directly expressed inside the target cells through cl...

Title : Identification and Characterization of an Acinetobacter baumannii Biofilm - Associated 1 Protein 2 Running Title : A . baumannii biofilm - associated protein 3 Byline :

Molecular analysis of the Acinetobacter baumannii biofilm - associated 1 protein 2 3

3 H. M. Sharon Goh, Scott A. Beatson, Makrina Totsika, Danilo G. Moriel, Minh-Duy 4 Phan, Jan Szubert, Naomi Runnegar, Hanna E. Sidjabat, David L. Paterson, Graeme R. 5 Nimmo, Jeffrey Lipman and Mark A. Schembri 6 7 Australian Infectious Diseases Research Centre, School of Chemistry and Molecular 8 Biosciences, The University of Queensland, Brisbane QLD 4072, Australia. 9 Pathology Queensland C...

Adjuvant role of Pseudomonas flagellin for Acinetobacter baumannii biofilm associated protein

AIM To study immunogenicity of Pseudomonas N terminal flagellin as an adjuvant for Acinetobacter baumannii (A. baumannii) biofilm associated protein (Bap). METHODS The N terminal flagellin gene was amplified. The pET28a (+) and polymerase chain reaction products were digested with HindIII and EcoR I. The ligation of N terminal flagellin into pET28a (‏+) was performed using T4 DNA ligase and w...

Iron and Acinetobacter baumannii Biofilm Formation

Acinetobacter baumannii is an emerging nosocomial pathogen, responsible for infection outbreaks worldwide. The pathogenicity of this bacterium is mainly due to its multidrug-resistance and ability to form biofilm on abiotic surfaces, which facilitate long-term persistence in the hospital setting. Given the crucial role of iron in A. baumannii nutrition and pathogenicity, iron metabolism has bee...